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Trican - DANGEROUS SIDE EFFECTS

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Trican Warnings and Dangers

Trican is used to treat fungal infections, including yeast infections of the vagina, mouth, throat, esophagus (tube leading from the mouth to the stomach), abdomen (area between the chest and waist), lungs, blood, and other organs. Trican is also used to treat meningitis (infection of the membranes covering the brain and spine) caused by fungus.

Trican is also used to prevent yeast infections in patients who are likely to become infected because they are being treated with chemotherapy or radiation therapy before a bone marrow transplant (replacement of unhealthy spongy tissue inside the bones with healthy tissue). Trican is in a class of antifungals called triazoles. It works by slowing the growth of fungi that cause infection.

Trican is a brand name for the drug Fluconazole.

Use of Trican has been associated with liver (hepatic) injury, including death, in patients with serious underlying medical conditions.

Cases of severe reaction leading to skin loss (exfoliative disorder) have been recorded.

Approximately 26% of patients experience some adverse side effects from Trican including:
  • Headache
  • Dizziness
  • Diarrhea
  • Stomach pain
  • Heartburn
  • Change in ability to taste food
  • Mistaking one taste for another
  • Upset stomach
  • Extreme tiredness
  • Unusual bruising or bleeding
  • Lack of energy
  • Loss of appetite
  • Pain in the upper right part of the stomach
  • Yellowing of the skin or eyes
  • Flu-like symptoms
  • Dark urine
  • Pale stools
  • Seizures
  • Rash
  • Hives
  • Itching
  • Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • Difficulty breathing
  • Difficulty swallowing
  • Indigestion
  • Nausea

Trican therapy has been associated with QT interval prolongation, which may lead to serious cardiac arrhythmias. Thus it is used with caution in patients with risk factors for prolonged QT interval such as electrolyte imbalance or use of other drugs which may prolong the QT interval (particularly cisapride).

High concentrations of Trican have been detected in human breast milk from patients receiving Trican therapy; it should not be used by breastfeeding mothers.

Tell your doctor and pharmacist if you are allergic to Trican, other antifungal medications such as itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend) or any other medications.

Do not take cisapride (Propulsid) while taking Trican.

Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking, especially the following:
  • Amiodarone (Cordarone)
  • Anticoagulants (blood thinners) such as warfarin (Coumadin)
  • Astemizole (Hismanal)
  • Benzodiazepines such as midazolam (Versed)
  • Cyclosporine (Neoral, Sandimmune)
  • Disopyramide (Norpace)
  • Diuretics (water pills) such as hydrochlorothiazide (HydroDIURIL, Microzide)
  • Dofetilide (Tikosyn)
  • Erythromycin (E.E.S, E-Mycin, Erythrocin)
  • Isoniazid (INH, Nydrazid)
  • Moxifloxacin (Avelox)
  • Oral contraceptives (birth control pills)
  • Oral medicine for diabetes such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glycron, others), and tolbutamide (Orinase)
  • Phenytoin (Dilantin)
  • Pimozide (Orap)
  • Procainamide (Procanbid, Pronestyl)
  • Quinidine (Quinidex)
  • Rifabutin (Mycobutin)
  • Rifampin (Rifadin, Rimactane)
  • Sotalolol (Betapace)
  • Sparfloxacin (Zagam)
  • Tacrolimus (Prograf)
  • Terfenadine (Seldane)
  • Theophylline (TheoDur)
  • Thioridazine (Mellaril)
  • Valproic acid (Depakene, Depakote)
  • Zidovudine (Retrovir)

Tell your doctor if you drink or have ever drunk large amounts of alcohol and if you have or have ever had cancer; acquired immunodeficiency syndrome (AIDS); an irregular heartbeat; or heart, kidney or liver disease.

Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Trican, call your doctor.

Symptoms of overdose may include:
  • Hallucinations (seeing things or hearing voices that do not exist)
  • Extreme fear that others are trying to harm you

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