Sporanox - DANGEROUS SIDE EFFECTS
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Sporanox Warnings and Dangers
Sporanox capsules are prescribed to treat fungal infections that begin in the lungs and can spread through the body. Sporanox capsules are also used to treat fungal infections of the fingernails and/or toenails. Sporanox oral solution is used to treat yeast infections of the mouth and throat and suspected fungal infections in patients with fever and certain other signs of infection. Sporanox is in a class of antifungals called triazoles. It works by slowing the growth of fungi that cause infection.
Sporanox is a brand name for the drug Itraconazole.
Sporanox can cause congestive heart failure (condition in which the heart cannot pump enough blood through the body).
Tell your doctor if you have or have ever had heart failure; a heart attack; an irregular heartbeat; any other type of heart disease; lung, liver, or kidney disease; or any other serious health problem.
If you experience any of the following symptoms, stop taking Sporanox and, call your doctor immediately:
- Shortness of breath
- Coughing up white or pink phlegm
- Excessive tiredness
- Fast heartbeat
- Swelling of the feet, ankles, or legs
- Sudden weight gain
People who take Sporanox may experience the following side effects:
- Diarrhea or loose stools
- Stomach pain
- Sore or bleeding gums
- Sores in or around the mouth
- Muscle pain
- Decreased sexual desire or ability
- Runny nose and other cold symptoms
- Unusual dreams
- Excessive tiredness
- Loss of appetite
- Upset stomach
- Yellowing of the skin or eyes
- Dark urine
- Pale stools
- Tingling or numbness of the hands or feet
- Fever, chills, or other signs of infection
- Frequent or painful urination
- Shaking hands that you cannot control
- Difficulty breathing or swallowing
Use of Sporanox has been associated with serious hepatotoxicity, including liver failure and death. Some of these cases occurred within the first week of use.
Life-threatening irregularities in heart rhythms (cardiac dysrhythmias), and sudden death have occurred when patients were using medications in addition to Sporanox, such as Quinidine. Cases of congestive heart failure and pulmonary edema have also been experienced.
Do not take the following medications while you are taking Sporanox. If you do you may experience serious irregular heartbeats:
- Cisapride (Propulsid)
- Dofetilide (Tikosyn)
- Pimozide (Orap)
- Quinidine (Quinaglute, Quinidex, others)
Talk to your doctor about the risks of taking Sporanox.
Tell your doctor and pharmacist if you are allergic to Sporanox; other antifungal medications such as fluconazole (Diflucan), ketoconazole (Nizoral), or voriconazole (Vfend); or any other medications.
If you are taking Sporanox oral solution, tell your doctor if you are allergic to saccharin or sulfa medications.
Do not take Sporanox if you are taking any of the following medications:
- Ergot-type medications such as dihydroergotamine (D.H.E. 45, Migranal)
- Ergoloid mesylates (Germinal, Hydergine)
- Ergonovine (Ergotrate)
- Ergotamine (Bellergal-S, Cafergot, Ergomar, Wigraine)
- Methylergonovine (Methergine)
- Methysergide (Sansert)
- Lovastatin (Mevacor)
- Simvastatin (Zocor)
- Triazolam (Halcion)
Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking, especially:
- Alfentanil (Alfenta)
- Alprazolam (Xanax)
- Anticoagulants (blood thinners) such as warfarin (Coumadin)
- Atorvastatin (Lipitor)
- Buspirone (BuSpar)
- Busulfan (Myleran)
- Calcium channel blockers such as amlodipine (Norvasc), felodipine (Plendil), isradipine (Dynacirc), nifedipine (Adalat,
- Procardia) nicardipine (Cardene) nimodipine (Nimotop), nisoldipine (Sular), and verapamil (Calan, Covera, Isoptin,
- Carbamazepine (Tegretol)
- Cerivastatin (Baycol) (not available in the United States)
- Cilostazol (Pletal)
- Clarithromycin (Biaxin)
- Cyclosporine (Neoral, Sandimmune)
- Diazepam (Valium)
- Digoxin (Lanoxin)
- Disopyramide (Norpace)
- Docetaxel (Taxotere)
- Eletriptan (Relpax)
- Erythromycin (E.E.S., Erythrocin, E-Mycin)
- Halofantrine (Halfan)
- HIV protease inhibitors such as indinavir (Crixivan), ritonavir (Norvir), and saquinavir (Fortovase, Invirase)
- Isoniazid (INH, Nydrazid)
- Medications for erectile dysfunction such as sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra)
- Midazolam (Versed)
- Nevirapine (Viramune)
- Oral contraceptives (birth control pills)
- Oral medicine for diabetes
- Phenobarbital (Luminal, Solfoton)
- Phenytoin (Dilantin)
- Rifabutin (Mycobutin)
- Rifampin (Rifadin, Rimactane)
- Sirolimus (Rapamune)
- Steroids such as dexamethasone (Decadron), budesonide (Entocort EC), and methylprednisolone (Medrol)
- Tacrolimus (Prograf)
- Trimetrexate (Neutrexin)
- Vinblastine (Velban)
- Vincristine (Oncovin)
- Vinorelbine (Navelbine)
Many other medications may also interact with Sporanox, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
You should know that Sporanox may remain in your body for several months after you stop taking it. Tell your doctor that you have recently stopped taking Sporanox before you start taking any other medications during the first few months after your treatment.
If you are taking an antacid, take it 1 hour before or 2 hours after you take Sporanox.
Tell your doctor if you have or have ever had AIDS, cystic fibrosis (an inborn disease that causes problems with breathing, digestion, and reproduction), or any condition that decreases the amount of acid in your stomach.
Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should not take Sporanox to treat nail fungus if you are pregnant or could become pregnant. You may start to take Sporanox to treat nail fungus only on the second or third day of your menstrual period when you are sure you are not pregnant. You must use effective birth control during your treatment and for 2 months afterward. If you become pregnant while taking Sporanox to treat any condition, call your doctor immediately.
One of the ingredients in Sporanox oral solution caused cancer in some types of laboratory animals. It is not known whether people who take Sporanox solution have an increased risk of developing cancer. Talk to your doctor about the risks of taking Sporanox solution.
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