Itraconazole is Dangerous

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Itraconazole - DANGEROUS SIDE EFFECTS
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Itraconazole Warnings and Dangers

Itraconazole capsules are prescribed to treat fungal infections that begin in the lungs and can spread through the body. Itraconazole capsules are also used to treat fungal infections of the fingernails and/or toenails. Itraconazole oral solution is used to treat yeast infections of the mouth and throat and suspected fungal infections in patients with fever and certain other signs of infection. Itraconazole is in a class of antifungals called triazoles. It works by slowing the growth of fungi that cause infection.

Itraconazole is a generic drug sold under the brand name Sporanox.

Itraconazole can cause congestive heart failure (condition in which the heart cannot pump enough blood through the body).

Tell your doctor if you have or have ever had heart failure; a heart attack; an irregular heartbeat; any other type of heart disease; lung, liver, or kidney disease; or any other serious health problem.

If you experience any of the following symptoms, stop taking Itraconazole and, call your doctor immediately:

Shortness of breath Coughing up white or pink phlegm Weakness Excessive tiredness Fast heartbeat Swelling of the feet, ankles, or legs Sudden weight gain
People who take Itraconazole may experience the following side effects:

Diarrhea or loose stools
Constipation
Gas
Stomach pain
Heartburn
Sore or bleeding gums
Sores in or around the mouth
Headache
Dizziness
Sweating
Muscle pain
Decreased sexual desire or ability
Nervousness
Depression
Runny nose and other cold symptoms
Unusual dreams
Excessive tiredness
Loss of appetite
Upset stomach
Vomiting
Yellowing of the skin or eyes
Dark urine
Pale stools
Tingling or numbness of the hands or feet
Fever, chills, or other signs of infection
Frequent or painful urination
Shaking hands that you cannot control
Rash
Hives
Itching
Difficulty breathing or swallowing

Use of Itraconazole has been associated with serious hepatotoxicity, including liver failure and death. Some of these cases occurred within the first week of use.

Life-threatening irregularities in heart rhythms (cardiac dysrhythmias), and sudden death have occurred when patients were using medications in addition to Itraconazole, such as Quinidine. Cases of congestive heart failure and pulmonary edema have also been experienced.

Do not take the following medications while you are taking Itraconazole. If you do you may experience serious irregular heartbeats:

Cisapride (Propulsid)
Dofetilide (Tikosyn)
Pimozide (Orap)
Quinidine (Quinaglute, Quinidex, others)

Talk to your doctor about the risks of taking itraconazole.

Tell your doctor and pharmacist if you are allergic to Itraconazole; other antifungal medications such as fluconazole (Diflucan), ketoconazole (Nizoral), or voriconazole (Vfend); or any other medications.

If you are taking itraconazole oral solution, tell your doctor if you are allergic to saccharin or sulfa medications.

Do not take itraconazole if you are taking any of the following medications:

Ergot-type medications such as dihydroergotamine (D.H.E. 45, Migranal)
Ergoloid mesylates (Germinal, Hydergine)
Ergonovine (Ergotrate)
Ergotamine (Bellergal-S, Cafergot, Ergomar, Wigraine)
Methylergonovine (Methergine)
Methysergide (Sansert)
Lovastatin (Mevacor)
Simvastatin (Zocor)
Triazolam (Halcion)

Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking, especially:

Alfentanil (Alfenta)
Alprazolam (Xanax)
Anticoagulants (blood thinners) such as warfarin (Coumadin)
Atorvastatin (Lipitor)
Buspirone (BuSpar)
Busulfan (Myleran) Calcium channel blockers such as amlodipine (Norvasc), felodipine (Plendil), isradipine (Dynacirc), nifedipine (Adalat, Procardia) nicardipine (Cardene) nimodipine (Nimotop), nisoldipine (Sular), and verapamil (Calan, Covera, Isoptin, Verelan)
Carbamazepine (Tegretol)
Cerivastatin (Baycol) (not available in the United States)
Cilostazol (Pletal)
Clarithromycin (Biaxin)
Cyclosporine (Neoral, Sandimmune)
Diazepam (Valium)
Digoxin (Lanoxin)
Disopyramide (Norpace)
Docetaxel (Taxotere)
Eletriptan (Relpax)
Erythromycin (E.E.S., Erythrocin, E-Mycin)
Halofantrine (Halfan)
HIV protease inhibitors such as indinavir (Crixivan), ritonavir (Norvir), and saquinavir (Fortovase, Invirase)
Isoniazid (INH, Nydrazid)
Medications for erectile dysfunction such as sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra)
Midazolam (Versed)
Nevirapine (Viramune)
Oral contraceptives (birth control pills)
Oral medicine for diabetes
Phenobarbital (Luminal, Solfoton)
Phenytoin (Dilantin)
Rifabutin (Mycobutin)
Rifampin (Rifadin, Rimactane)
Sirolimus (Rapamune)
Steroids such as dexamethasone (Decadron), budesonide
(Entocort EC), and methylprednisolone (Medrol)
Tacrolimus (Prograf)
Trimetrexate (Neutrexin)
Vinblastine (Velban)
Vincristine (Oncovin)
Vinorelbine (Navelbine)

Many other medications may also interact with Itraconazole, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

You should know that Itraconazole may remain in your body for several months after you stop taking it. Tell your doctor that you have recently stopped taking Itraconazole before you start taking any other medications during the first few months after your treatment.

If you are taking an antacid, take it 1 hour before or 2 hours after you take Itraconazole. Tell your doctor if you have or have ever had AIDS, cystic fibrosis (an inborn disease that causes problems with breathing, digestion, and reproduction), or any condition that decreases the amount of acid in your stomach.

Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should not take Itraconazole to treat nail fungus if you are pregnant or could become pregnant. You may start to take Itraconazole to treat nail fungus only on the second or third day of your menstrual period when you are sure you are not pregnant. You must use effective birth control during your treatment and for 2 months afterward. If you become pregnant while taking Itraconazole to treat any condition, call your doctor immediately.

One of the ingredients in itraconazole oral solution caused cancer in some types of laboratory animals. It is not known whether people who take Itraconazole solution have an increased risk of developing cancer. Talk to your doctor about the risks of taking Itraconazole solution.